Recent research has identified a new gene associated with an increased risk of developing Parkinson’s disease. The Australian Parkinson’s Genetics Study (APGS), funded by Shake It Up Australia and The Michael J. Fox Foundation, has discovered this gene through extensive genetic analysis.
Parkinson’s disease has been linked to several genetic mutations, including those in the LRRK2 gene. Mutations in LRRK2, such as the G2019S variant, are known to enhance kinase activity and are relatively common causes of familial Parkinson’s disease, particularly among certain populations.
In South Asian populations, including India, the prevalence of known genetic mutations associated with Parkinson’s disease, such as those in the LRRK2 gene, appears to be lower compared to other populations. However, recent studies have identified novel LRRK2 variants specific to the Indian population, although their significance in disease development requires further investigation.
The identification of new genetic factors contributing to Parkinson’s disease is crucial for developing targeted therapies and preventive strategies. Ongoing research, including large-scale genetic studies like the APGS, continues to enhance our understanding of the genetic architecture of Parkinson’s disease across diverse populations.
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